Publications of the Week Autonomous Circadian Rhythms in the Human Hepatocyte Regulate Hepatic Drug Metabolism and Inflammatory ResponsesScience Advances | April 25, 2024Critical aspects of physiology and cell function exhibit self-sustained ~24-hour variations termed circadian rhythms. In…karnottApril 25, 2024 Read More
Publications of the Week An Esophagus Cell Atlas Reveals Dynamic Rewiring During Active Eosinophilic Esophagitis and RemissionDing, J., et al. | April 24, 2024Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis…karnottApril 24, 2024 Read More
Publications of the Week BCAA-Nitrogen Flux in Brown Fat Controls Metabolic Health Independent of ThermogenesisVerkerke, A., et al. | April 23, 2024Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT…karnottApril 23, 2024 Read More
Publications of the Week Targeted Therapies Prime Oncogene-Driven Lung Cancers for Macrophage-Mediated DestructionVaccaro, K., et al. | April 19, 2024Macrophage immune checkpoint inhibitors, such as anti-CD47 antibodies, show promise in clinical trials for solid…karnottApril 19, 2024 Read More
Publications of the Week Episymbiotic Saccharibacteria TM7x Modulates the Susceptibility of Its Host Bacteria to Phage Infection and Promotes Their CoexistenceZhong, Q., et al. | April 15, 2024The factors influencing the interaction between phages and bacteria, as well as their long-term coexistence,…karnottApril 15, 2024 Read More
Publications of the Week Discovery of Antibiotics That Selectively Kill Metabolically Dormant BacteriaZheng, E., et al. | April 10, 2024There is a need to discover and develop non-toxic antibiotics that are effective against metabolically…karnottApril 10, 2024 Read More
Publications of the Week Direct Interrogation of Context-Dependent GPCR Activity with a Universal Biosensor PlatformJanicot, R., et al. | April 8, 2024G protein-coupled receptors (GPCRs) are the largest family of druggable proteins encoded in the human…karnottApril 8, 2024 Read More
Publications of the Week Gut Microbiome and Metabolome Profiling in Framingham Heart Study Reveals Cholesterol-Metabolizing BacteriaLi, C., et al. | April 4, 2024Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our…karnottApril 4, 2024 Read More
Publications of the Week Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients with SynucleinopathiesGibbons, C., et al. | April 3, 2024Can skin biopsy detect phosphorylated α-synuclein in individuals with synucleinopathies such as Parkinson disease (PD),…karnottApril 3, 2024 Read More
Publications of the Week Neutrophils Bearing Adhesive Polymer Micropatches as a Drug-Free Cancer ImmunotherapyKumbhojkar, N., et al. | April 2, 2024Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-tumoural phenotype in the…karnottApril 2, 2024 Read More